Dr. D'Agostino's primary area of statistical research involves developing methods for using propensity scores in medical research. He has published extensively in this area and has presented many lectures and workshops in this topic. In addition to this research, Dr. D’Agostino is the Director of the Biostatistics Core for the Wake Forest School of Medicine Comprehensive Cancer Center and the Co-Director of the CDC funded SEARCH (Search for Diabetes in Youth) Data Coordinating Center. He has also been the Principal Investigator on seven other RO1-grants/subcontracts funded by NIH as well as being the lead statistician on numerous other NIH and Foundation funded research projects.
Dr. D'Agostino has published over 185 manuscripts and book chapters in areas of statistical methodology, cardiovascular disease, diabetes, cancer and genetics. He has extensive experience in the design and analysis of clinical trials, observational studies and large scale epidemiologic studies including the Insulin Resistance Atherosclerosis Study (IRAS), Subclinical Cardiovascular Disease Study (MESA) and the Search for Diabetes in Youth Study (SEARCH).
Lynne E. Wagenknecht, DrPH, Professor and Associate Director, Division of Public Health Sciences, Wake Forest University School of Medicine, is a chronic disease epidemiologist with an extensive research portfolio in the epidemiology and genetics of cardiovascular disease, diabetes, and obesity. She is the Principal Investigator on various multi-center grants whose activities span both clinical centers and coordinating centers. Dr. Wagenknecht directs (or had directed) the clinical centers for several NHLBI-sponsored studies: ARIC (Atherosclerosis Risk in Communities) and FHS-SCAN (Family Heart Study of coronary and aortic calcification).
She is also the Principal Investigator of an NHLBI-sponsored observational study coordinating center: the IRAS (Insulin Resistance Atherosclerosis Study) Family Study, a study of the genetics of insulin resistance and abdominal adiposity. Dr. Wagenknecht is Co-Principal Investigator of the Look AHEAD Coordinating Center funded by the NIDDK, a lifestyle intervention trial aimed to reduce CVD outcomes in 5000 obese persons with type 2 DM. She is a co-investigator on the Diabetes Heart Study and on the African American Diabetes Heart Study, both being conducted at WFU, and examining the genetics of sub-clinical coronary heart disease in siblings with type 2 DM. She is active in the American Diabetes Association and is currently an Associate Editor for Diabetes.
Dr. Wagenknecht serves on the Oversight Committee for the CARE program (Candidate-gene Association Resource). She also teaches and mentors students in the WFU Clinical and Population Translational Science graduate program.