The SEARCH-CC was a case-control project conducted from 2003 to 2006 that studied 10-22 year old children and adolescents with or without diabetes, focusing on type 2 diabetes in youth and drawing upon the CDC funded SEARCH diabetes project in Colorado and South Carolina. The SEARCH project ascertained cases of diabetes in youth, collected immunologic, clinical, and metabolic information, and classified cases as type 1, type 2 or other types (hybrids) of diabetes. SEARCH-CC recruited appropriate controls aged 10-22 years from three ethnic backgrounds including African Americans (AA), Hispanics (H), and non-Hispanic whites (NHW). SEARCH-CC added selected measurements not available in SEARCH to explore or describe:
For more information, contact Ralph B. D'Agostino, Jr., PhD at rdagosti@wakehealth.edu
The SEARCH Nutrition Ancillary Study, funded by NIH/NIDDK and conducted from 2008 to 2012, aims to evaluate nutritional determinants of sustained beta cell function in youth with T1DM, and to explore nutritional correlates of CVD risk profile in youth with T1DM. The overall goal of SNAS is to examine associations of nutritional factors with 1) the progression of insulin secretion defects, and 2) the presence of CVD risk factors in youth with T1DM. SNAS will address the following Specific Aims:
For more information, contact Joan Thomas at joan_thomas@unc.edu
This NIH/NIDDK funded effort seeks to identify how diabetes incidence rates vary spatially, independent of demographic characteristics. The study aims to:
For more information, contact Angela Liese, PhD at liese@sc.edu
Samples from the SEARCH study were evaluated for several forms of monogenic diabetes including SUR1, Kir 6.2, and MODY, and clinical characteristics of such cases will be described. This work was funded by JDRF.
For more information, contact Cate Pihoker at catherine.pihoker@seattlechildrens.org
This study, funded by NHLBI, is recruiting non-diabetic controls, and is collecting data on CVD sub-clinical outcomes among 800 10-25 year old adolescents and young adults from Colorado and Ohio. Using case-control and within case longitudinal designs, SEARCH CVD will address specific aims related to the presence of, and risk factors for, preclinical CVD in youth with and without T1D.
For more information, contact Dana Dabelea, MD, Phd at Dana.Dabelea@ucdenver.edu
The purpose of this study is to evaluate the short and long-term effects of air pollution on cardiovascular risk. We will examine the acute effects of air pollution exposures on inflammatory markers and measures of cardiovascular function, as well as the chronic effects of these exposures on cardiovascular structure. Understanding the role of air pollution on inflammation and subclinical CVD among children and youth with type 1 diabetes could have a major impact on treatment approaches and behavioral recommendations.
For more information, contact Robin Puett, PhD at rpuett@umd.edu
Section 1 | Executive Summary |
Section 2 | Center Descriptions |
Section 3 | Study Organization |
Section 4A | Registry Study Objectives |
Section 4B | Cohort Study Objectives |
Section 5A |
Registry Study Case Ascertainment & Data Collection |
Section 5B | Cohort Study Data Collection |
Section 6A | Registry Study Statistical Considerations |
Section 6B | Cohort Study Statistical Considerations |
Section 7 | Data Management |
Section 8A | Registry Study Human Subjects |
Section 8B | Cohort Study Human Subjects |
The SEARCH Study invites Investigators interested in childhood Diabetes Research to collaborate on matters of interest to the field of childhood Diabetes. Please feel free to contact us to express your interest in collaboration.