Ancillary Study Descriptions

The SEARCH-CC was a case-control project conducted from 2003 to 2006 that studied 10-22 year old children and adolescents with or without diabetes, focusing on type 2 diabetes in youth and drawing upon the CDC funded SEARCH diabetes project in Colorado and South Carolina. The SEARCH project ascertained cases of diabetes in youth, collected immunologic, clinical, and metabolic information, and classified cases as type 1, type 2 or other types (hybrids) of diabetes. SEARCH-CC recruited appropriate controls aged 10-22 years from three ethnic backgrounds including African Americans (AA), Hispanics (H), and non-Hispanic whites (NHW). SEARCH-CC added selected measurements not available in SEARCH to explore or describe:

  1. Specific etiologic hypotheses in the cases classified by SEARCH as type 2 diabetes.
  2. Cardiovascular risk factor differences in youth with diabetes and non-diabetic controls.
  3. Among controls, insulin resistance and secretion differences according to levels of the same risk factors under study.
  4. Among youth with diabetes, the relationship between depression and diabetes management, quality of life, and self-concept.
  5. Among youth with and without diabetes, the relationship between diabetes and depression and related psychosocial factors.

For more information, contact Ralph B. D'Agostino, Jr., PhD at

The SEARCH Nutrition Ancillary Study, funded by NIH/NIDDK and conducted from 2008 to 2012, aims to evaluate nutritional determinants of sustained beta cell function in youth with T1DM, and to explore nutritional correlates of CVD risk profile in youth with T1DM. The overall goal of SNAS is to examine associations of nutritional factors with 1) the progression of insulin secretion defects, and 2) the presence of CVD risk factors in youth with T1DM. SNAS will address the following Specific Aims:

  1. To evaluate selected nutritional factors as potential determinants of preserved ß-cell function in youth with T1DM.
  2. To evaluate selected nutritional factors in relation to CVD risk factors among youth with T1DM.

For more information, contact Joan Thomas at

This NIH/NIDDK funded effort seeks to identify how diabetes incidence rates vary spatially, independent of demographic characteristics. The study aims to:

  1. Describe and map the spatial distribution of incident pediatric diabetes, including Type 1 and Type 2 in the ethnically and geographically diverse SEARCH populations from South Carolina, Ohio, Colorado, and Washington;
  2. Evaluate the association of incidence of Type 1 and Type 2 diabetes with geographic and neighborhood characteristics (location, urbanization, population density, socio-economic characteristics) in a series of statistical, ecologic analyses;
  3. To explore the extent to which aggregate geographical and neighborhood characteristics influence risk of Type 1 or Type 2, once established individual-level risk factors are taken into account, in a multi-level analysis

For more information, contact Angela Liese, PhD at

Samples from the SEARCH study were evaluated for several forms of monogenic diabetes including SUR1, Kir 6.2, and MODY, and clinical characteristics of such cases will be described. This work was funded by JDRF.

For more information, contact Cate Pihoker at

This study, funded by NHLBI, is recruiting non-diabetic controls, and is collecting data on CVD sub-clinical outcomes among 800 10-25 year old adolescents and young adults from Colorado and Ohio. Using case-control and within case longitudinal designs, SEARCH CVD will address specific aims related to the presence of, and risk factors for, preclinical CVD in youth with and without T1D.

  1. To describe the presence and correlates of sub-clinical abnormalities in cardiovascular (CVD) structure and function among 400 adolescents and young adults with T1D and 400 non-diabetic controls.
  2. To explore the rate of change and risk factors for changes in measures of arterial stiffness (pulse wave velocity, augmentation index and brachial distensibility) in youth with T1D.

For more information, contact Dana Dabelea, MD, Phd at

The purpose of this study is to evaluate the short and long-term effects of air pollution on cardiovascular risk. We will examine the acute effects of air pollution exposures on inflammatory markers and measures of cardiovascular function, as well as the chronic effects of these exposures on cardiovascular structure. Understanding the role of air pollution on inflammation and subclinical CVD among children and youth with type 1 diabetes could have a major impact on treatment approaches and behavioral recommendations.

For more information, contact Robin Puett, PhD at

Study Protocol

Download Study Protocol

Section 1 Executive Summary
Section 2 Center Descriptions
Section 3 Study Organization
Section 4A Registry Study Objectives
Section 4B Cohort Study Objectives
Section 5A Registry Study Case Ascertainment
& Data Collection
Section 5B     Cohort Study Data Collection
Section 6A Registry Study Statistical Considerations
Section 6B Cohort Study Statistical Considerations
Section 7 Data Management
Section 8A Registry Study Human Subjects
Section 8B Cohort Study Human Subjects


The SEARCH Study invites Investigators interested in childhood Diabetes Research to collaborate on matters of interest to the field of childhood Diabetes. Please feel free to contact us to express your interest in collaboration.